B.Pharma Important Question
BP-302T,
Physical Pharmaceutics – I,
III Sem, RGPV, B.Pharmacy
UNIT 1 – Solubility of Drugs
Q.1 State and explain Distribution law with its limitation and application. (RGPV Dec 2023)
Q.2 Describe with the help of example the importance of diffusion principle in biological system. (RGPV Dec 2023)
Q.3 Describe various physicochemical properties of drug molecules and their applications. (RGPV June 2020)
Q.4 What is Raoult’s law? Give its applications and limitations. (RGPV June 2020)
Q.5 Explain in detail the factors influencing solubility of drugs. (RGPV June 2020)
Q.6 Define Solubility. Explain the mechanism of solute-solvent interaction. (RGPV Nov 2019)
Q.7 Explain the Distribution Law. Write down its limitation and applications. (RGPV Nov 2019)
UNIT 2 – States of Matter & Properties of Matter
Q.1 Explain working and construction of Polarimeter. (RGPV Dec 2023)
Q.2 How will you describe phase diagram to determine matter at given temperature and Pressure? (RGPV Dec 2023)
Q.3 Give justification for the following: (RGPV Dec 2023)
a) Lacrimal fluid is dilute with distilled water.
b) EDTA improves stability of Ascorbic acid in pharmaceutical formulation.
c) Cyclodextrin form monomolecular complexes with drugs.
Q.4 What is meant by aerosols and give the formulation of inhalers along with its evaluation? (RGPV June 2020)
Q.5 Discuss in detail about various physicochemical properties of drug molecule. (RGPV Nov 2019)
UNIT 3 – Surface & Interfacial Phenomenon
Q.1 Define Griffin’s HLB. Discuss methods of HLB calculation. (RGPV Dec 2023)
Q.2 Write a detailed note on critical micelle concentration and its significance in Pharmacy. (RGPV Dec 2023)
Q.3 Explain the methods of measurement of surface and interfacial tension. (RGPV June 2020)
Q.4 What is Spreading Coefficient? Explain absorption at solid interface. (RGPV Nov 2019)
Q.5 What are Surface active agents? Discuss measurement of surface tension. (RGPV Nov 2019)
UNIT 4 – Complexation & Protein Binding
Q.1 Classify complexes with its application in pharmaceutical formulation. (RGPV Dec 2023)
Q.2 How the binding of drugs to protein can influence their action? (RGPV Dec 2023)
Q.3 Give the concept of protein binding along with its kinetics. (RGPV June 2020)
Q.4 What is Complexation? Give the classification of complexation and applications. (RGPV June 2020)
Q.5 Give the classification of Complexes. Write down their methods of analysis in detail. (RGPV Nov 2019)
UNIT 5 – pH, Buffers & Isotonic Solutions
Q.1 Derive the Henderson-Hasselbalch equation for buffer combination containing weak. (RGPV Dec 2023)
Q.2 Define Buffer capacity. Explain standard buffer solution used in Pharmacy. (RGPV Dec 2023)
Q.3 Give the methods of determination of pH. (RGPV June 2020)
Q.4 Discuss types of buffer in pharmaceutical and biological systems. (RGPV June 2020)
Q.5 Explain Buffer Capacity. Write the role of buffers in pharmaceutical and biological systems. (RGPV Nov 2019)
Extra Questions
Q.1 Write short note on the following: (RGPV Dec 2023)
a) Measurement of pH
b) Laws of Diffusion
c) Dissociation constant
Q.2 Write short note on the following: (RGPV Dec 2023)
a) Solubilisation process
b) Azeotropic mixtures
c) Application of dipole moment in Pharmacy
Q.3 Write short notes on any three. (RGPV June 2020)
a) HLB balance
b) Binary solutions
c) Polymorphism
d) Dipole moment
Q.4 Write short notes on (Any three) (RGPV Nov 2019)
a) Protein Binding
b) Aerosols
c) Eutectic Mixtures
d) Real solutions
e) Sorensen’s pH scale
— Best of Luck for Exam —
