B.Pharma Important Question
BP-402T,
Medicinal Chemistry-I,
IV Sem, RGPV, B.Pharmacy
UNIT 1 – Introduction to Medicinal Chemistry
Q.1 Write down a detail note on physiochemical properties related to biological action. (RGPV June 2024)
Q.2 Explain the various Principle involved in drug biotransformation. (RGPV June 2024)
Q.3 Describe Phase I Drug metabolism with example. (RGPV Nov 2023)
Q.4 Explain the Solubility and Partition Coefficient. (RGPV Nov 2023)
Q.5 Explain bioisosterism with examples. (RGPV Nov 2023)
Q.6 Explain bioisosterism and its role in medicinal chemistry. (RGPV June 2023)
Q.7 Write note on Drug Metabolism. (RGPV June 2023)
Q.8 Explain the following physicochemical parameters related to biological activity with examples. (RGPV June 2023)
a) Solubility
b) Protein Binding
c) Chelation
UNIT 2 – Drugs Acting on Autonomic Nervous System
Q.1 Give the synthesis and mechanism of action of Neostigmine OR Salbutamol. (RGPV June 2024)
Q.2 Define and classify adrenergic drugs with structure, IUPAC, synthesis and Uses of Phenylephrine. (RGPV June 2024)
Q.3 Give the Biosynthesis and catabolism of Acetylcholine. (RGPV June 2024)
Q.4 What do you mean by Beta Blocking Agents. Discuss the structure synthesis and contraindications of Propranolol. (RGPV June 2024)
Q.5 Give synthesis of Phenylephrine. (RGPV Nov 2023)
Q.6 Give the SAR of beta blockers. (RGPV Nov 2023)
Q.7 Describe biosynthesis of catecholamine. (RGPV Nov 2023)
Q.8 Exemplify direct and indirect acting Sympathomimetic agents giving their structures. (RGPV June 2023)
Q.9 Classify adrenergic antagonists with structures. Give synthesis of propranolol. (RGPV June 2023)
UNIT 3 – Cholinergic Neurotransmitters
Q.1 Write a detailed note on biosynthesis and catabolism of catecholamine. (RGPV June 2024)
Q.2 Define and Classify anticonvulsants with structure of each class. Give the Synthesis and MOA of Phenytoin. (RGPV June 2024)
Q.3 Write a detailed note on indirectly acting cholinergic drugs. (RGPV June 2024)
Q.4 Classify cholinergic blocking agents with example. (RGPV Nov 2023)
Q.5 Give synthesis and uses of Neostigmine. (RGPV Nov 2023)
Q.6 Write examples of reversible and irreversible cholinesterase inhibitors giving their structures. (RGPV June 2023)
Q.7 Give name and structure of natural and synther cholinergic blocking agents. (RGPV June 2023)
UNIT 4 – Drugs Acting on Central Nervous System
Q.1 Discuss the classification and SAR of Barbiturates. (RGPV June 2024)
Q.2 Define and classify Anti-Psychotics Drugs. Write down the mechanism of action and SAR of Chlorpromazine hydrochloride. (RGPV June 2024)
Q.3 What is convulsion? Give mechanism of action of anticonvulsant agents. (RGPV Nov 2023)
Q.4 Write down the Classification and SAR of Phenothiazine. (RGPV Nov 2023)
Q.5 Write down the MOA of Sedatives drugs. (RGPV Nov 2023)
Q.6 What are Sedative and Hypnotics. Discuss role of barbiturates and benzodiazepines giving chemical synthesis of any one drug under each category. (RGPV June 2023)
Q.7 Explain classification of anticonvulsants with SAR and mode of action of phenothiazine. (RGPV June 2023)
UNIT 5 – General Anesthetics
Q.1 Give the Structure, IUPAC, Synthesis and Therapeutic uses of Mefenamic acid OR Ibuprofen. (RGPV June 2024)
Q.2 Classify General anesthetics and give the mechanism of action structure and synthesis of Methohexital sodium. (RGPV June 2024)
Q.3 Write exhausted notes on narcotic analgesics. Explain the SAR of Morphine. (RGPV June 2024)
Q.4 Classify Anti-inflammatory agents with example. (RGPV Nov 2023)
Q.5 Write down the SAR of Morphine analogues. (RGPV Nov 2023)
Q.6 What are General anesthetics? Give synthesis of Halothane. (RGPV Nov 2023)
Q.7 Describe general anaesthetics with examples. Give synthesis of any two. (RGPV June 2023)
Q.8 Classify Narcotic and Non narcotic analgesics. Discuss SAR of morphine analogs. (RGPV June 2023)
Extra Questions
Q.1 Write detailed note on (any two). (RGPV June 2024)
a) Optical and Geometrical isomerism
b) Protein binding
c) Dissociative anesthetics
Q.2 Write short notes on (Any three). (RGPV Nov 2023)
a) Hydrogen bonding
b) SAR of barbiturates
c) Narcotic antagonists
d) Synthesis of Dicyclomine hydrochloride
e) MOA of Beta adrenergic blockers
— Best of Luck for Exam —
