B.Pharma Important Question
BP-501T,
Medicinal Chemistry-II,
V Sem, RGPV, B.Pharmacy
UNIT 1 – Antihistaminic Agents
Q.1. What are antihistamines? What do you mean by H1 and H2 antagonist? Discuss them with examples. Write synthesis of Diphenhydramine HCL. (RGPV May 2024)
Q.2. Write structure and uses of Hydrochlorothiazide and Amiloride. Outline the synthesis and uses of Chlorothiazide. (RGPV Nov 2023)
Q.3. List the histamine H₂-receptor antagonists with suitable structure. Give the SAR of H1 and H₂ receptor blockers. (RGPV May 2023)
Q.4. What are non-sedative antihistamines? Enumerate them with the chemical structure. (RGPV Dec 2024)
Q.5. SAR of H1-receptor blockers. (RGPV Dec 2024)
Q.6. Write a short note on non-sedative antihistamines. (RGPV Nov 2023)
UNIT 2 – Anti-anginal Drugs
Q.1. What are antianginal drugs? Classify calcium channel blocker with suitable examples. Write SAR for calcium channel blocker. (RGPV May 2024)
Q.2. Explain the mechanism of action and structure of ACE inhibitors. (RGPV May 2023)
Q.3. What are Bile-Acid Sequestrants? Give the structure, MOA and uses of Cholestyramine and Colestipol. (RGPV Dec 2024)
Q.4. Write about the Phosphodiesterase-5 (PDE5) inhibitors. Draw the structure and uses of Sildenafil and Tadalafil. (RGPV Nov 2023)
Q.5. What is HMG-CoA reductase inhibitor? Write the structure and uses of Lovastatin. (RGPV Nov 2023)
Q.6. What are anti-hyperlipidemic agents? Give the classification and structure of HMG-CoA reductase inhibitor with MOA. (RGPV Dec 2024)
UNIT 3 – Anti-arrhythmic Drugs
Q.1. Discuss nomenclature, stereochemistry, and metabolism of steroids. Write detailed note on corticosteroids. (RGPV May 2024)
Q.2. What are Oral contraceptives? Give the structure, MOA and uses of any two drugs. (RGPV May 2023)
Q.3. What are thyroid and anti-thyroid drugs? Illustrate the structure and uses of Levothyroxine. (RGPV Dec 2024)
Q.4. Write about steroidal nomenclature and stereochemistry. (RGPV May 2023)
Q.5. Write the structure and uses of Diethylstilbestrol. (RGPV Dec 2024)
UNIT 4 – Drugs Acting on Endocrine System
Q.1. What are antimetabolites? Classify them. Write synthesis of Methotrexate. (RGPV May 2024)
Q.2. What are alkylating agents? Explain with the chemical reaction about alkylating mechanism in anti-cancer therapy. (RGPV Nov 2023)
Q.3. Enumerate the agents used in this category and describe the synthesis and uses of any one of them. (RGPV Nov 2023)
Q.4. What is CHF? Write about Cardiac glycoside with suitable structure. (RGPV Dec 2024)
Q.5. What are oral anticoagulants? Write the SAR for Coumarin Derivatives. (RGPV Nov 2023)
Q.6. Give a comprehensive account of hormones that are potent as antineoplastic agents. (RGPV Dec 2024)
UNIT 5 – Antidiabetic Agents
Q.1. Classify oral hypoglycemic agents in detail. Discuss MOA and SAR of Sulfonyl ureas. Write synthesis of Tolbutamide. (RGPV May 2024)
Q.2. What is anesthesia? Write structural classification of local anesthetics. Discuss SAR and MOA of local anesthetics. (RGPV May 2024)
Q.3. Give the MOA and SAR for local anesthetics. (RGPV Nov 2023)
Q.4. Write in detail about Thiazolidinediones. Give the Structure, synthesis, and uses of Tolbutamide. (RGPV May 2023)
Q.5. List the structure and uses of the following oral hypoglycemic agents: (RGPV Nov 2023)
a) Biguanides derivative
b) α-Glucosidase inhibitors
Q.6. Write a comprehensive account of the synthesis of Furosemide and Chlorothiazide. (RGPV Dec 2024)
Extra Questions
Q.1. Write a short note on any three of the following: (RGPV May 2024)
a) Vasodilators
b) Drug used in Erectile dysfunction
c) Antihyperlipidemic agents
d) Drugs used in CHF
Q.2. Write synthesis of any three of the following: (RGPV May 2024)
a) Promethazine
b) Warfarin
c) Acetazolamide
d) Dibucaine
Q.3. How are antiarrhythmic drugs classified? Give the synthetic protocol with MOA and uses of Disopyramide Phosphate and Lidocaine Hydrochloride. (RGPV May 2023)
Q.4. Discuss the following with regard to antineoplastic agents: (RGPV May 2023)
a) Pteridines derivative
b) Taxol derivatives
— Best of Luck for Exam —
