B.Pharma Important Question
BP-601T,
Medicinal Chemistry-III,Β Β
VI Sem, RGPV, B.Pharmacy
UNIT I
Q.1 What you understand by Beta Lactam antibiotics classify them? Write an exhausted note on chemistry of Penicillin. (RGPV May 2024)
Q.2 Discuss the SAR of Tetracyclines with structure and Mechanism of chlortetracycline. (RGPV May 2024)
Q.3 Classify αΊ-Lactam antibiotics with example. (RGPV May 2023)
Q.4 Give classification on penicillin with suitable example of each category. Brief about αΊ-lactamase inhibitors. (RGPV May 2022)
UNIT II
Q.1 Explain the SAR of Quinolines as a antimalarial drug with etiology of malaria. (RGPV May 2024)
Q.2 What do you mean by Prodrug? Discuss general requirements and qualities for Prodrug designing. (RGPV May 2024)
Q.3 Describe Etiology of malaria. (RGPV May 2023)
Q.4 Give the SAR of quinolones. (RGPV May 2023)
Q.5 Classify Macrolide antibiotics with example. (RGPV May 2023)
Q.6 Describe Basic concepts and application of prodrugs design. (RGPV May 2023)
Q.7 What is Prodrug? Elaborate basic concepts and applications of Prodrug designing. (RGPV May 2022)
Q.8 Explain etiology of malaria, give structure activity relationship of Quinolines as Anti-malarial agents. (RGPV May 2022)
UNIT III
Q.1 Define and classify Anti-tubercular drugs. Write down the mechanism of action and SAR of Isoniazid. (RGPV May 2024)
Q.2 Write a detailed note on Urinary Tract anti-infective agent. (RGPV May 2024)
Q.3 Classify antiviral Agents and give the mechanism of action of Reverse Transcriptase inhibitors. (RGPV May 2024)
Q.4 Give SAR and synthesis of Isoniazid. (RGPV May 2023)
Q.5 Write down the Synthesis of Acyclovir. (RGPV May 2023)
Q.6 Write down the MOA of Antiviral agents. (RGPV May 2023)
Q.7 Write a note on Antiviral agents. (RGPV May 2022)
Q.8 What are MDR TB and XDR TB? Give the classification of anti-tubercular drugs. Write synthesis of Para amino salicylic acid. (RGPV May 2022)
UNIT IV
Q.1 Give the synthesis and mechanism of action of Miconazole OR Tolnaftate. (RGPV May 2024)
Q.2 Define and Classify Sulphonamides with structure of each class. Give the Synthesis and MOA of Sulphacetamide sodium with SAR. (RGPV May 2024)
Q.3 Give the Structure, IUPAC, Synthesis and Therapeutic uses of PAS OR Dapsone. (RGPV May 2024)
Q.4 Define and classify anthelmintics with structure, IUPAC, synthesis and Uses of Diethylcarbamazine Citrate. (RGPV May 2024)
Q.5 Write the SAR and Mechanism of Imidazole derivative Anti-Protozoal drugs. (RGPV May 2024)
Q.6 What is antiprotozoal Agents? Give synthesis of Metronidazole. (RGPV May 2023)
Q.7 Give classification of Sulfonamides. (RGPV May 2023)
Q.8 Give synthesis and uses of Trimethoprim. (RGPV May 2023)
Q.9 Classify anthelmintics agents with example. (RGPV May 2023)
Q.10 What are sulfonamide antibiotics? Write different ways to classify sulphonamides. Write synthesis and mechanism of action of sulfamethoxazole. (RGPV May 2022)
Q.11 Synthesis of Metronidazole and Chloroquine. (RGPV May 2022)
Q.12 Write a note on Anthelmintics & Antiprotozoal drugs. (RGPV May 2022)
UNIT V
Q.1 Write a detailed note on Hammet’s electronic and Trafts steric parameter. (RGPV May 2024)
Q.2 Write exhausted notes on QSAR. Describe the role of Partition Coefficient in new drug designing. (RGPV May 2024)
Q.3 Write down the physicochemical parameters of QSAR. (RGPV May 2023)
Q.4 Explain the solid phase synthesis. (RGPV May 2023)
EXTRA QUESTIONS
Q.1 Write detailed note on (any two) (RGPV May 2024)
a) Aminoglycosides
b) Antifungal drugs
c) Solid and solution phase synthesis in Combinatorial chemistry
Q.2 Write short notes on (Any three): (RGPV May 2023)
a) Synthesis of Dapsone
b) SAR of Ciprofloxacin
c) Hansch analysis
d) Synthesis of Para amino salicylic acid
e) MOA of Tetracycline’s
Q.3 Write synthesis, mechanism of action and uses of (any three) (RGPV May 2022)
a) Miconazole
b) Chloramphenicol
c) Isoniazid
d) Trimethoprim
e) Dapsone
— Best of Luck for Exam —
