B.Pharma Important Question

BP-803T(H)/BP-804T(C)

Computer Aided Drug Design,  

VIII Sem, RGPV, B.Pharmacy

UNIT-I Introduction to Drug Discovery and Development

Q.1 Discuss various stages of Drug discovery and development. (RGPV Jun 2020)

UNIT-II Quantitative Structure Activity Relationship (QSAR)

Q.1 Discuss various physicochemical parameters used in Quantitative Structure Activity Relationship (QSAR).  (RGPV Jun 2020)

UNIT-III Molecular Modeling and virtual screening techniques

Q.1 Explain role of various techniques of virtual screening in the process of drug discovery and development.  (RGPV Jun 2020)

Q.2 Compare various aspects related to the rigid docking, flexible docking and manual docking. (RGPV Jun 2020)

UNIT-IV Informatics & Methods in drug design

Q.1 Give significance of bioinformatics and chemo informatics databases in drug discovery and development.  (RGPV Jun 2020)

UNIT-V Molecular Modeling

Q.1 Write a note on rational approaches to lead discovery based on traditional medicine and lead discovery based on clinical observation.  (RGPV Jun 2020)

Q.2 Explain concept of molecular mechanics and quantum mechanics, discuss methods of Energy minimization.  (RGPV Jun 2020)

Extra Questions

Q.1 Write short note on any two of followings. (RGPV Jun 2020)

a) Bioisosterism

b) COMFA and COMSIA

c) De novo drug design

— Best of Luck for Exam —